Ozone Therapy that has been actively developing over the last 15 years remains the priority of scientific investigations in many research centers and has deserved to be called as Medicine of 21st Century. Our many-years experience allows us making a conclusion that Ozone Therapy is characterized by simplicity of application, good tolerance by patients, almost full absence of side-effects or adverse reactions and high medical-social and economic efficiency. Ozone Therapy has a wide range of action, produces a bactericidal, virucidal, fungicidal, immunomodulating, antihypoxic, detoxication effect, is good tolerated by patients and has almost no side-effects. The use of Medical Ozone reduces treatment time, lethality and grade of disability.